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Pyruvate Kinase Deficiency

Pyruvate Kinase Deficiency, or PK Deficiency, is the lack of a critical red blood cell enzyme (pyruvate kinase), which regulates the final step in the conversion of glucose to energy. As a result, red blood cells are not able to metabolize the energy required for the cells to function normally, which leads to a change in the cell membranes, a buildup of sodium ions inside the cell, a resulting swelling of the cell (as water molecules follow the buildup of sodium), and an eventual lysing (bursting) of the cell. Furthermore, there is a shortened life span of red blood cells as the abnormal cells are destroyed by the spleen and liver. To make matters worse, PK deficiency, through the changes described above, can shift the normal process by which hemoglobin stores and releases oxygen to body tissues. The end result of these changes produces "hemolytic anemia," which is a reduction in red blood cells and tissue oxygenation due to the rupture of abnormal red blood cells.

PK Deficiency Inheritance
Pyruvate Kinase Deficiency is an autosomal recessive trait, which means that, for a dog to have PK Deficiency, both parents must be either affected dogs themselves or carriers. Affected dogs will have two copies of the bad gene, while carriers will only have one copy and will not clinically show symptoms, although studies have shown that carriers do have a reduction in normal red blood cell enzyme activity.
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Recent Visitor Comments
Irish Terrier
To Train or not to train. for an Irish Terrier puppy, it will be well advised to find an experienced terrier trainer. Balance with proper socialization early on in your puppy's life. Get your puppy accustomed to nail trimming and grooming now. You don't necessarily need to groom an I.T. puppy, but get them used to the feel of a smooth soft bristle baby brush (for example). If you wait until later, it will not go as smoothly.

Irish Terrier
Choosing an Irish Terrier puppy with a sweet temperament is important, but no guarantee forever. Be very wise when introducing to other dogs, make sure they are also very nice dogs. If exposed to aggressive behavior, an Irish Terrier will of course defend itself, and there will be no turning back. Avoid situations where your pup is forced to defend itself. That is your job, to keep your puppy safe at all times and in every situation.

Glen of Imaal Terrier
Recently we rescued of Glen of Imaal from our local SPCA. She is 4 yrs old and is a very focused little girl. A mind of her own, not real affectionate, but very loyal at the same time. She has trained me well.

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Latest Blog Entries

Featured Breed -

Brussels Griffon

The Brussels Griffon At a Glance
Recognized By AKC
Country of Origin Belgium
Life Expectancy 12 - 15 yrs
Height Range 7 - 8 in
Weight Range 8 - 10 lbs
Colors Red, beige, black & tan, or black. No white hairs or markings
Trainability Can be good with a skilled and patient trainer; they tend to be stubborn
With Children Good with older children; can be nervous around overly active younger children
With Animals Very good; does well with other dogs and cats
Climate Intolerant of cold weather
Indoor/Outdoor Indoor with some outdoor time preferred; can do well in apartment/condo
Exercise Reqd Moderate to high; walks and play time are sufficient
Grooming Reqd Proper coat requires regular brushing and hand stripping by a knowledgeable groomer.
Brussels Griffon Information
The Brussels Griffon is a breed of toy dog named for the griffin, a mythological animal, which it is said to resemble. The Brussels griffon seems to have descended from a dog used by 17th-century Belgian peasants to rid their stables of rats. The ancestry of the modern breed includes the Affenpinscher, the Smooth-Coated Pug, and the Ruby Spaniel.

Conformation

Brussels Griffons have distinctive short, upturned faces, large, round heads, short noses, and unusually large and prominent black eyes. The male Griffon from 7 to 12 pounds. The female is slightly larger.

Disposition

The Brussels Griffon is intelligent, alert, sensitive, and full of self-importance with an almost human expression.

They are inside pets, good with other pets and children of all ages.

There are two types of coats, rough and smooth. They come in colors of Beige, Black, Black and Beige and Red.

Courtesy of Kelly Crawford, KMC-Kennels.
Click to find:   Brussels Griffon Puppies For Sale   |   Brussels Griffon Breeders   |   Brussels Griffon Information

Dog Question of the Week

Some answers to last week's question:
Do you prefer big dogs or small dogs, and why?
This Week's Question:
What breed do you think is the cutest?
I perfer big dogs on the whole, because I think they are more adaptable, rough-and-ready, easily trained and are better with children, and simply easier to live with. But larger dogs are not for everyone and are likely to make a small home seem even smaller.
Ella from Des Monies, Iowa, USA
big dogs, they don't potty all over the house!
shell from taylor, mi , USA
Dog Question of the Week
What breed do you think is the cutest?
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