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Globoid Cell Leukodystrophy

Globoid Cell Leukodystrophy, also known as Krabbe's Disease, is a genetically inherited condition belonging to a category known as "storage diseases." A storage disease occurs when a particular enzyme, which is necessary for a normal process within the body, is deficient, and as a result, the compound which the enzyme normally acts upon builds up. This build-up leads to the expression of the disease and its symptoms, typically not at birth, but generally at a consistent age for each specific storage disease.

In the case of Globoid Cell Leukodystrophy, the deficient enzyme is galactocerebroside beta-galactosidase. This enzyme normally is involved in the breakdown of fats in the brain and spinal cord. When it is deficient, the compound galactocerebroside begins to build up. Galactocerebroside is a component of myelin, which is the fatty substance that surrounds and insulates nerve cells, keeping the electrical impulses properly isolated within the cells. When Galactocerebroside builds up, the production of myelin is affected, and as a result, there is a progressive loss of the myelin sheath on nerve cells in the brain and spinal cord.

Age of Onset
Puppies affected with Globoid Cell Leukodystrophy are normal at birth, but they may begin showing symptoms as early as four weeks or as late as six months. Basset Hounds are the exception, since they may not show symptoms for several years.

Symptoms of Globoid Cell Leukodystrophy
Symptoms are typically progressive (gradually worsening) and include stiffness when walking, weakness, lack of balance and coordination, tremors, loss of control (especially of hindquarters), and typically will eventually progress to paralysis and possible blindness. As would be expected, there are also generally behavioral changes that occur in conjunction with the physiological symptoms.
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Recent Visitor Comments
Irish Terrier
To Train or not to train. for an Irish Terrier puppy, it will be well advised to find an experienced terrier trainer. Balance with proper socialization early on in your puppy's life. Get your puppy accustomed to nail trimming and grooming now. You don't necessarily need to groom an I.T. puppy, but get them used to the feel of a smooth soft bristle baby brush (for example). If you wait until later, it will not go as smoothly.

Irish Terrier
Choosing an Irish Terrier puppy with a sweet temperament is important, but no guarantee forever. Be very wise when introducing to other dogs, make sure they are also very nice dogs. If exposed to aggressive behavior, an Irish Terrier will of course defend itself, and there will be no turning back. Avoid situations where your pup is forced to defend itself. That is your job, to keep your puppy safe at all times and in every situation.

Glen of Imaal Terrier
Recently we rescued of Glen of Imaal from our local SPCA. She is 4 yrs old and is a very focused little girl. A mind of her own, not real affectionate, but very loyal at the same time. She has trained me well.

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Featured Breed -

English Setter

The English Setter At a Glance
Recognized By AKC
Country of Origin England
Life Expectancy 10 - 15 yrs
Height Range 22 - 27 in
Weight Range 40 - 80 lbs
Colors White base coat with even flecking all over preferred. Flecks may be blue, orange, lemon, or liver. Tri colors are blue beltons with tan points. Field variety is more prone to patching.
Trainability Very trainable as long as a soft hand is used. Perceived as stubborn by those using a heavy-handed training method.
With Children Excellent. Very tolerant. Very high bite inhibition
With Animals Excellent with other animals except, of course, birds and rodents
Climate Comparable to humans
Indoor/Outdoor Indoor as they bond very tightly to their family
Exercise Reqd Fenced yard. Active as puppies but bench variety is calm in the house as adults. Field bred variety much more active
Grooming Reqd Field bred dogs need minimal grooming. Bench variety need routine grooming appointments
English Setter Information
The English setter is believed to have originated in England about 400 years ago. The field variety was primarily developed in America by Mr. Llwyellin. The bench variety was developed in this country by Mr. Laverack. The field variety is smaller both in height and weight than the bench variety. Both will usually hunt. The field variety, however, has a much higher energy level and is suitable for hunters on horse back as they range fairly far. The bench is more of a gentleman's hunting companion as he will usually not range far and is more suitable for hunters on foot. English setters are easily house trained. Like most puppies, they tend to chew when young. Like most sporting dogs, they should be taught to come relably when called before any attempts to let them off of a leash. This is a very soft, sensitive breed and does best with similar training methods. The English setter is, in general, a robust dog not commonly afflicted with ailments. The only problems relatively common to the breed are deafness, hip dysplasia and elbow dysplasia. Judious breeding by conscientious breeders has decreased the incidence of these problems in many lines of English setters. Prospective buyers should ask if parents have had their hearing BAER (Brainstem Auditory Evoked Response) tested and their hips and elbows evaluated by the OFA (Orthopedic Foundation for Animals). The English setter has maintained a very faithful following in many countries because of the breed's lovely disposition. The English setter is a wonderful family dog.

Information courtesy of Kaliber English Setters
Click to find:   English Setter Puppies For Sale   |   English Setter Breeders   |   English Setter Information

Dog Question of the Week

Some answers to last week's question:
Do you think dogs can read our emotions?
This Week's Question:
What is your dog's favorite game to play?
Totally... they seem to know when we need their affection the most, or when we are in a good mood and want to play.
Joelle from Kinston, NC, USA
I don't think they so much read our emotions as it is them responding to the way we act or when our routines or way of behaving changes, then they notice something is different.
Will from Aberdeen, TX, USA
of course, body movements are words to dogs, our emotions can show all over us...and dogs read that, have great sense of energy
Debi from pilot mtn., NC, USA
Dog Question of the Week
What is your dog's favorite game to play?
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