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Globoid Cell Leukodystrophy

Globoid Cell Leukodystrophy, also known as Krabbe's Disease, is a genetically inherited condition belonging to a category known as "storage diseases." A storage disease occurs when a particular enzyme, which is necessary for a normal process within the body, is deficient, and as a result, the compound which the enzyme normally acts upon builds up. This build-up leads to the expression of the disease and its symptoms, typically not at birth, but generally at a consistent age for each specific storage disease.

In the case of Globoid Cell Leukodystrophy, the deficient enzyme is galactocerebroside beta-galactosidase. This enzyme normally is involved in the breakdown of fats in the brain and spinal cord. When it is deficient, the compound galactocerebroside begins to build up. Galactocerebroside is a component of myelin, which is the fatty substance that surrounds and insulates nerve cells, keeping the electrical impulses properly isolated within the cells. When Galactocerebroside builds up, the production of myelin is affected, and as a result, there is a progressive loss of the myelin sheath on nerve cells in the brain and spinal cord.

Age of Onset
Puppies affected with Globoid Cell Leukodystrophy are normal at birth, but they may begin showing symptoms as early as four weeks or as late as six months. Basset Hounds are the exception, since they may not show symptoms for several years.

Symptoms of Globoid Cell Leukodystrophy
Symptoms are typically progressive (gradually worsening) and include stiffness when walking, weakness, lack of balance and coordination, tremors, loss of control (especially of hindquarters), and typically will eventually progress to paralysis and possible blindness. As would be expected, there are also generally behavioral changes that occur in conjunction with the physiological symptoms.
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Recent Visitor Comments
Irish Terrier
To Train or not to train. for an Irish Terrier puppy, it will be well advised to find an experienced terrier trainer. Balance with proper socialization early on in your puppy's life. Get your puppy accustomed to nail trimming and grooming now. You don't necessarily need to groom an I.T. puppy, but get them used to the feel of a smooth soft bristle baby brush (for example). If you wait until later, it will not go as smoothly.

Irish Terrier
Choosing an Irish Terrier puppy with a sweet temperament is important, but no guarantee forever. Be very wise when introducing to other dogs, make sure they are also very nice dogs. If exposed to aggressive behavior, an Irish Terrier will of course defend itself, and there will be no turning back. Avoid situations where your pup is forced to defend itself. That is your job, to keep your puppy safe at all times and in every situation.

Glen of Imaal Terrier
Recently we rescued of Glen of Imaal from our local SPCA. She is 4 yrs old and is a very focused little girl. A mind of her own, not real affectionate, but very loyal at the same time. She has trained me well.

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Featured Breed -

Coton de Tulear

The Coton de Tulear At a Glance
Recognized By UKC, FCI
Country of Origin Madagascar
Life Expectancy 16 - 18 yrs
Height Range 9 - 11 in
Weight Range 10 - 12 lbs
Colors White; few shadings of light grey or red roan are permitted on ears. Permitted elsewhere but not desirable in show dog.
Trainability Very agile and wonderful companion dogs. With good breeder training they are very trainable and respond to love and kindness and a lot of praise. They aim to please you.
With Children Wonderful; these dogs love to play with children and are very loving
With Animals Very good. Because of their nature they love to play and be friends. They will respond well to other pets as long as they are gentle.
Climate A Coton can adapt to any reasonable climate.
Indoor/Outdoor Mostly indoor but loves to play outside
Exercise Reqd Minimal. These dogs entertain themselves and adapt to your lifestyle
Grooming Reqd Routine maintenance. Spray with water and comb every few days; clipping nails; cleaning ears.
Coton de Tulear Information
The Coton de Tulear originates from Madagascar, the world's fourth largest island, off the southeast coast of Africa. The breed dates back to the 15th century. Tp offset sailor's hardships and loneliness of ladies- , little white dogs were added to the passenger list. During a violent storm, a ship wrecked near Madagascar- all sailors and ladies perished- while the little white dogs swam to shore. It is assumed some little white dogs settled on the island, became wild again, met eventually with the local terriers resulting in the Coton. Natives fell in love with these little white dogs, domesticated and offered them to the King and Malagasy nobles.
At the turn of the century, French colonists also fell under the spell of these little dogs, took them back to their native country, raised the Cotons as pets.
The Coton de Tulear is a small, sweet "cottony"long haired- , mainly white dog, weighing 10-12 lbs.He is a happy, little companion, often acting like a clown in the show ring. They are very eager and intelligent and form strong bonds with their masters. The Coton thrives on love, food, human companionship and protection from its family. The Coton is seldom sick and lives to be 15-18 yrs old.
The United States of America Coton de Tulear Club (USACTC) was born in the late 1994 and in1995 "Cherry Blossom" of ARBA there were 20 entries. The breed is noted as the "ANTI-STRESS DOG OF THE 20th CENTURY.



Found principally in the port city of Tulear, this small Madagascan dog whose beautiful white or nearly all white coat has - just like the rip fruit of the cotton bush - a texture similar to a wad of cotton wool. Coton is french for cotton. The texture of the breed's coat makes it stand out from almost all other dog breeds. It is obvious that this dog is related to the Bichon but we really know very little about its origin. It was becoming extinct and France brought some over and started to breed these wonderful dogs. They were brought to America in 1974 by Dr. Robert Jay Russell from Madagascar. This is a very sweet natured dog that will adapt to its environment and aims to please. They are wonderful companion dogs and do well with children and other animals. They require minimal exercise but will go for walks and romp and play like a child. If you are not looking for a warm, loving, faithful and happy go lucky companion, this dog is not for you. These dogs are also wonderful to travel with if you are looking for a pet to keep you company when you are away from home. Their health is very good and the quality breeders have been very careful to keep this line pure. Always question your breeder and see the environment the puppy is born in. There are always good and bad in everything so beware and get to know your breeder. They do not shed and are non allergic dogs. However, there is always the acception to the rule with allergies and I feel, you should test first to make sure you are okay if you have serious problems. These dogs also do not have doggy smell.
Click to find:   Coton de Tulear Puppies For Sale   |   Coton de Tulear Breeders   |   Coton de Tulear Information

Dog Question of the Week

Some answers to last week's question:
Who is your favorite dog from TV or movies?
This Week's Question:
What is the best trick you have ever taught your dog?
Max (How the Grinch Stole Christmas)
Teresa from Waynesboro, VA, USA
Lassie
Aimee from Elk Falls, Kansas, USA
Asta, From The Thin Man Movie (1934)
Samantha from Riggins, South Carolina, USA
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